What question did this study set out to answer?

This research aims to explore PGAM5 as a potential drug target for reducing organ injury.

February 6, 2026Open Access

Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury

LCLin ChenYangzhou University HLHaibo LiCentral South University QZQingtain Zhu

Key Points

This research aims to explore PGAM5 as a potential drug target for reducing organ injury.
Screening for PGAM5-specific inhibitors
Evaluation of compound PD
Assessment of safety and translational potential
Established PGAM5 as a druggable target
Identified PD with strong safety profile
Demonstrated effectiveness in attenuating multi-organ injury

Abstract

These findings establish PGAM5 as a druggable target in organ injury and identify PD as a natural compound with favorable safety and strong translational potential, providing a foundation for necroptosis-targeted therapeutic development.

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