Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People with Multiple Sclerosis

Key Points

• This research aims to explore how daily use of psychoactive substances relates to fatigue, pain, stress, and depressive symptoms in individuals with multiple sclerosis.
• Analyzed daily substance use patterns
• Measured fatigue, pain, stress, and depressive symptoms
• Utilized longitudinal observational data
• Psychoactive substance use was linked to increased fatigue and pain episodes
• Stress and depressive symptoms were often reported alongside higher substance use
• Findings suggest both beneficial and adverse regulatory effects of substance use on MS symptoms