A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis

Key Points

• The research aims to assess the effectiveness of pharmacological agents and growth factors in regenerating bony defects associated with chronic periodontitis.
• Conducted a network meta-analysis of randomized controlled trials
• Evaluated combinations of pharmacological agents and PRF (Platelet-Rich Fibrin)
• Focused on outcomes of bone fill and attachment gain
• Combination therapies showed improved bone fill compared to standard methods
• Significant attachment gain was observed in patients using adjunctive pharmacological agents
• Clinical outcomes were found to be predictable and beneficial for chronic periodontitis patients