A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis

Shivani Sanjay Koli; Surekha Rathod; Abhay Kolte; Priyanka Jaiswal; Sakshi Kotecha

doi:10.1186/s12903-026-07742-8

February 3, 2026BMC Oral HealthOpen Access

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis

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Key Points

The research aims to assess the effectiveness of pharmacological agents and growth factors in regenerating bony defects associated with chronic periodontitis.
Conducted a network meta-analysis of randomized controlled trials
Evaluated combinations of pharmacological agents and PRF (Platelet-Rich Fibrin)
Focused on outcomes of bone fill and attachment gain
Combination therapies showed improved bone fill compared to standard methods
Significant attachment gain was observed in patients using adjunctive pharmacological agents
Clinical outcomes were found to be predictable and beneficial for chronic periodontitis patients

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Implication

Meta-analysis evaluates pharmacological agents' effectiveness in regenerating bone in chronic periodontitis, suggesting positive outcomes.

Abstract

The study provides clinically relevant evidence supporting the adjunctive use of pharmacologic agents with PRF to optimize regenerative outcomes. Such combinations can improve bone fill and attachment gain, offering predictable benefits for patients with chronic periodontitis.

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Koli et al. (2026) studied this question.

synapsesocial.com/papers/698584b78f7c464f23008193 https://doi.org/10.1186/s12903-026-07742-8

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A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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