What question did this study set out to answer?

To develop a 3D model of ovarian cancer metastasis using a decellularised peritoneal matrix and investigate therapy responses.

February 6, 2026EBioMedicine0 citationsOpen Access

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A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response

CGChristiane Helgestad GjerdeHaukeland University Hospital KKKatrin KleinmannsHaukeland University Hospital ALAnika LangerUniversity of Bergen

Key Points

To develop a 3D model of ovarian cancer metastasis using a decellularised peritoneal matrix and investigate therapy responses.
Created a 3D culture model using a decellularised peritoneal matrix.
Applied therapy agents to the model to assess response.
Measured changes in cancer cell behavior and viability.
The model accurately reflects ovarian cancer metastasis.
Certain therapies showed enhanced effectiveness in the 3D environment.
Response to treatments varied significantly compared to traditional 2D cultures.

Abstract

Financial support was provided by the University of Bergen, Helse Vest RHF (F-12183-D10616, 779, 911182, 912035, and 912146), Helse Bergen HF (240222), the Norwegian Cancer Society (6833652 and 182735), the Research Council of Norway grants (250317, 326300, 223250, 262652, and 295910), the Novo Nordisk Foundation (NNF21OC0070381), the Kolbjørn Brambani Legat for Kreftforskning, the National Institute of Health (R01CA199646) and the Swedish Cancer Society (21 1888 Pj).

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A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response

Key Points

Abstract

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