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This research examines the effects of hexadecanamide on colitis and its influence on gut microbiome composition.

February 6, 2026Open Access

Hexadecanamide alleviates experimental colitis in mice and modifies the gut microbiome

LBLijuan BaoJilin University LJLei JINChinese University of Hong Kong YYyang yangBeijing University of Posts and Telecommunications

Key Points

This research examines the effects of hexadecanamide on colitis and its influence on gut microbiome composition.
Induced colitis in mice using DSS (dextran sulfate sodium)
Administered hexadecanamide to evaluate its effects
Assessed inflammation levels, barrier integrity, and gut microbial composition
Hexadecanamide significantly reduced inflammation in colitis models
Improved integrity of the intestinal barrier was observed
Alterations in gut microbial composition were noted, indicating a healthier microbiome

Abstract

Overall, our findings suggest that HEX markedly ameliorates DSS-induced colitis by limiting inflammation, improving barrier integrity and regulating gut microbial composition. These results highlight the critical role of HEX in maintaining intestinal homeostasis and suggest its potential as a novel preventive and therapeutic strategy.

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