Computational Vascular Development Model Explaining Incidence of Notch in Retinopathy of Prematurity With Ultra-Widefield Optical Coherence Tomography

David A. Sutter; Austin D. Igelman; Aaron S Coyner; Georgios Stratis; Kevin Real; Mani K. Woodward; John Jackson; Yakub A. Bayhaqi; Shuibin Ni; Susan Ostmo; Yifan Jian; Michael F. Chiang; John Peter Campbell; Sunčica Čanić; Benjamin K. Young

doi:10.1167/iovs.67.2.10

February 3, 2026Investigative Ophthalmology & Visual ScienceOpen Access

Computational Vascular Development Model Explaining Incidence of Notch in Retinopathy of Prematurity With Ultra-Widefield Optical Coherence Tomography

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Key Points

To develop a computational model that explains vascular development patterns in retinopathy of prematurity.
Introduced a computational vascular development model.
Examined the foveal repulsive effect in relation to retinal vasculogenesis.
Utilized ultra-widefield optical coherence tomography for analysis.
The model elucidates varied patterns of retinal vasculogenesis, including notch formation.
Supports the need for future predictive models concerning vascular development.

Implication

Computational model explains retinal vasculogenesis patterns, indicating potential for future predictions in conditions like retinopathy of prematurity.

Abstract

This computational model introducing a foveal repulsive effect may explain varied retinal vasculogenesis patterns, like notch formation, and supports future predictive models.

Discussion

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Cite This Study

Sutter et al. (2026) studied this question.

synapsesocial.com/papers/698584b78f7c464f230081d8 https://doi.org/10.1167/iovs.67.2.10

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Computational Vascular Development Model Explaining Incidence of Notch in Retinopathy of Prematurity With Ultra-Widefield Optical Coherence Tomography

Key Points

Implication

Abstract

Discussion

Cite This Study

Computational Vascular Development Model Explaining Incidence of Notch in Retinopathy of Prematurity With Ultra-Widefield Optical Coherence Tomography

Key Points

Implication

Abstract

Discussion

Cite This Study

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