Polycythemia vera is a type of myeloproliferative neoplasm characterized by panmyelosis, with a predominant increase in erythrocyte mass. In contrast, monoclonal gammopathy of undetermined significance is classified as a premalignant plasma cell disorder and is characterized by elevated levels of monoclonal γ-globulin without associated bone lesions or clinical symptoms. Here, we present a case of the concurrent presence of wild-type transthyretin cardiac amyloidosis—not the amyloid light-chain type—and monoclonal gammopathy of undetermined significance in a patient with polycythemia vera. This case underscores the crucial importance of preforming histologic subtyping to ensure accurate diagnosis in older patients with undiagnosed cardiac amyloidosis.
Otoi et al. (Sun,) studied this question.
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