Combining network pharmacology and experimental validation to demonstrate that salidroside alleviates acute lung injury by inhibiting ferroptosis via the MAPK/GPX4 pathway

Key Points

• The research aims to explore how salidroside alleviates acute lung injury through the MAPK/GPX4 pathway.
• Utilized network pharmacology for drug-target interaction analysis.
• Conducted experimental validation of findings through in vitro studies.
• Examined the effects of salidroside on inflammatory response and oxidative stress levels.
• Salidroside significantly reduced inflammation and oxidative stress markers.
• Inhibition of ferroptosis was observed in lung tissue.
• The MAPK/GPX4 signaling pathway was modulated by salidroside treatment.