Identifying and characterizing a specific B cell subcluster related to proliferation in diffuse large B cell lymphoma (DLBCL).
Characterization of B cell subclusters in DLBCL.
Analysis of nucleotide metabolism pathways.
Exploration of potential treatment strategies in immune-oncology.
Discovery of a proliferative B cell subcluster associated with XBP1.
Link established between altered nucleotide metabolism and B cell proliferation.
Insights provided for developing new treatment strategies in cellular therapies.
Abstract
This analysis has identified and characterized the proliferation-related B cells in DLBCL, which may provide some ideas for the treatment strategies in immune-oncology and cellular therapies.