Mechanochemical intervention demonstrates regioselective chalcogenation in peptides, suggesting robust synthetic applications.
An iron-mediated direct chalcogenation of tyrosine-containing peptides has been developed. This protocol operates under mechanochemical conditions and exhibits broad functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated by the late-stage functionalization of pharmaceutical compounds. Preliminary mechanistic studies indicated that a radical pathway is likely to be operative.
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Yu et al. (2026) studied this question.
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