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The research aims to develop a nanofluidic system that mimics neural processing for biochemical signal discrimination.

February 6, 2026ACS Nano

Nanofluidic Confined DNA Aptamers for Neuromorphic Multiplex Discrimination

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Demonstrates neuromorphic signal processing in bioinspired systems, suggesting improved biochemical sensing capabilities.

The research aims to develop a nanofluidic system that mimics neural processing for biochemical signal discrimination.
Constructed a nanofluidic artificial postsynaptic membrane using confined DNA aptamers.
Utilized target-induced conformational switching to modulate ionic transport in nanochannels.
Integrated multiple aptamer-based units into a cascaded logic system for parallel signal processing.
Achieved 100% accurate discrimination of multiple biochemical targets.
Enabled dendritic multi-input integration and brain-like information fusion.
Demonstrated a shift from traditional one-probe models to multitarget recognition architectures.

Chen et al. (2026) studied this question.

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