A one-pot protocol reveals high-yield synthesis of xanthate-functionalized allylic sulfonyl fluorides, suggesting applications in medicinal chemistry.
A one-pot protocol for the addition of naturally rich alcohols, carbon disulfide and 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) for the selective synthesis of a class of novel xanthate-functionalized allylic sulfonyl fluorides has been developed, affording isolated yields up to 99%. Subsequent SuFEx transformations and the modification of natural and pharmaceutical compounds were achieved with remarkable efficiency, offering promising applications in biological and medicinal chemistry.
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Ajisafe et al. (2026) studied this question.
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