Key result
Post-TAVR stroke is linked to a ~422% increase in 30-day mortality.
Why the study?
Despite improvements in the safety of TAVR, the risk of stroke remains a significant concern.
What is the incidence of stroke after TAVR and does it increase mortality?
Meta-Analysis (n=585,593)
What is the incidence of stroke after TAVR and does it increase mortality?
Stroke occurs in 3.3% of patients within 30 days after TAVR and is associated with a 3- to 5-fold increase in short- and long-term mortality.
Stroke after TAVR markedly raises short-term mortality; confirms strong association in large pooled analysis.
Background Despite improvements in the safety of transcatheter aortic valve replacement (TAVR), the risk of stroke remains a significant concern. Purpose This meta-analysis aims to evaluate the incidence of stroke and its impact on major clinical outcomes in patients following TAVR. Methods A comprehensive literature search of Pubmed, Cochrane, and Scopus databases was conducted to identify relevant studies reporting stroke events up to 30 days post-procedure and associated mortality rates up to 1 year. A meta-analysis with odds ratio (OR) was performed using random effects model and heterogeneity was assessed using the I2 statistic. Results A total of 38 studies encompassing 585,593 patients were included in the meta-analysis. The pooled occurrence of stroke after TAVR was 3.3 % (95% CI: 2.6% to 4.2%). Stroke after TAVR was associated with >3 times greater risk of in-hospital mortality (OR 3.82; 95% CI: 3.43 to 4.25; p< 0.0001), >5 times greater risk of 30-day mortality (OR; 5.22, 95% CI: 4.35 to 6.25; p< 0.0001) and 3 times greater risk of 1year mortality (OR; 2.99, 95% CI: 2.24 to 4.0; p< 0.0001 ). Meta-regression results indicated a significant reduction in stroke incidence based on study publication year (p=0.038). Conclusions Post-procedure stroke following TAVR remains a significant and potentially preventable source of patient mortality. Gaining insight into these events' short- and long-term health implications may motivate developing and adopting effective preventive strategies.outcomes 1 outcomes 2
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Theodoropoulou et al. (2025) conducted a meta-analysis in Transcatheter aortic valve replacement (TAVR) (n=585,593). Stroke after TAVR vs. No stroke after TAVR was evaluated on in-hospital mortality (OR 3.82, 95% CI 3.43-4.25, p=<0.0001). Stroke after TAVR occurred in 3.3% of patients and was associated with a significantly increased risk of in-hospital mortality (OR 3.82; 95% CI 3.43-4.25; p<0.0001).
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