Key result
Post-TAVR stroke is associated with a 3-fold increase in 30-day mortality (aHR 3.17; 95% CI 2.87-3.49) and persistent mortality risk up to 5 years.
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Post-TAVR stroke remains a highly morbid complication associated with significantly increased short- and long-term mortality.
ost-transcatheter aortic valve replacement (TAVR) stroke is associated with substantial morbidity and mortality.1 In a prior analysis, post-TAVR stroke was associated with a 3-fold increase in 30day mortality (adjusted hazard ratio [aHR], 3.17 [95% CI, 2.87-3.49]),and the risk persisted in those who survived up to 5 years after TAVR (aHR, 1.18 [95% CI, 1.10-1.20]). 1 In addition, post-TAVR stroke was associated with an increased risk of all-cause readmission and recurrent stroke at 1 year. 1 The Valve Academic Research Consortium (VARC)-3 2 has categorized post-TAVR stroke into (1) periprocedural stroke: ≤30 days after the index procedure, which is subsequently classified into acute stroke (≤24 hours) and subacute stroke (>24 hours and ≤30 days); (2) early stroke: >30 days and ≤1 year after the index procedure; and (3) late stroke >1 year after the index procedure.
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Elkaryoni et al. (2024) conducted an editorial in Post-transcatheter aortic valve replacement (TAVR) stroke. Post-TAVR stroke was evaluated on 30-day mortality (aHR 3.17, 95% CI 2.87-3.49). Post-TAVR stroke is associated with a 3-fold increase in 30-day mortality (aHR 3.17; 95% CI 2.87-3.49) and persistent mortality risk up to 5 years.
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