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February 6, 2026Open Access

Synthesis, biocompatibility, and antimicrobial properties of glucose-based ionic liquids

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Authors

SJStefan JoppUniversity of RostockTFTabea FleischhammerLeibniz University HannoverALAntonina LavrentievaLeibniz University Hannover

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Implication

This work demonstrates the biocompatibility and antimicrobial effects of glucose-based ionic liquids, highlighting their potential against antibiotic resistance.

Key Points

  • The aim is to synthesize glucose-based ionic liquids and evaluate their biocompatibility and antimicrobial properties.
  • Synthesis of glucosyl imidazolium ionic liquids with variations in side chains and anions.
  • In vitro testing for biocompatibility using L929 mouse fibroblasts.
  • Assessment of antimicrobial activity using disk diffusion tests against various microbial strains.
  • Most CHILs exhibited excellent biocompatibility at a concentration of 10<sup>-2</sup> mol L<sup>-1</sup>.
  • Increased alkyl chain length and fluorinated anions correlated with higher cytotoxicity.
  • CHILs showed significant antimicrobial effects, particularly against Candida auris, with specific MIC and MFC values.

Cite This Study

Jopp et al. (2023) studied this question.

synapsesocial.com/papers/698585438f7c464f23008772https://doi.org/10.15488/20518
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Also Consider

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  1. 1Synthesis, physicochemical and antimicrobial properties of novel imidazolium based ionic liquids2024
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  4. 4Experimental and In Silico Comparative Study of Physicochemical Properties and Antimicrobial Activity of Carboxylate Ionic Liquids2024 · 4 citations
  5. 5Tracing the Antibacterial Performance of Bis-Imidazolium-based Ionic Liquid Derivatives2024 · 16 citations