Key result
Young FMT improves cardiac function by reducing phenylacetic acid from aged gut microbiota.
Why the study?
Aging increases cardiovascular disease risk, potentially linked to gut microbiota dysbiosis, but the critical bacterial taxa and metabolites driving age-related cardiac dysfunction remained to be identified.
Does young fecal microbiota transplantation improve cardiac function and reduce myocardial senescence in aged mice?
Does young fecal microbiota transplantation improve cardiac function and reduce myocardial senescence in aged mice?
Gut microbiota-derived phenylacetic acid promotes cardiac aging and systolic dysfunction via histone phenylacetylation, a process that can be reversed by young microbiota transplantation.
May support microbiota modulation for cardiac aging in mice; leaves open human translation and clinical relevance.
Aging elevates cardiovascular disease risk, potentially linked to gut microbiota dysbiosis, with distinct compositional differences observed between elderly and younger populations. This study aimed to identify critical bacterial taxa and metabolites driving age-related cardiac dysfunction and to delineate the gut microbiota/phenylacetic acid (PAA)/histone phenylacetylation/heart failure (HF) axis. Young and aged mice underwent reciprocal fecal microbiota transplantation (FMT) to assess cardiac aging phenotypes. Natural aging and FMT cohorts were analyzed via 16S rRNA sequencing, metabolomics, proteomics, and post-translational modification profiling to pinpoint PAA-associated mechanisms. Aged mice exhibited gut microbiota dysregulation, characterized by reduced Bacteroidetes and elevated Firmicutes/Bacteroidetes ratios, alongside increased circulating PAA. PAA facilitated histone phenylacetylation, activating senescence-associated genes in cardiomyocytes, thereby promoting myocardial senescence and systolic dysfunction. Conversely, young microbiota transplantation restored microbial diversity, suppressed PAA levels, and attenuated histone modifications, improving cardiac function . Immunoblotting confirmed diminished histones phenylacetylation in young-FMT hearts. These results unveil a novel pathway linking gut microbiota-derived PAA to epigenetic-driven cardiac aging and HF, proposing microbiota modulation or PAA inhibition as potential therapeutic strategies.
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Xie et al. (2025) studied Cardiac aging and heart failure. Fecal microbiota transplantation (FMT) vs. Natural aging or reciprocal FMT was evaluated on Cardiac aging phenotypes, microbial diversity, histone phenylacetylation, and cardiac function. Fecal microbiota transplantation from young mice restored microbial diversity, suppressed phenylacetic acid levels, and attenuated histone modifications, improving cardiac function in aged mice.
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