Research develops 3D-printed vascular scaffolds with enhanced mechanical properties and antibacterial coatings, indicating improved integration and infection resistance.
Key Points
The study aims to develop and characterize 3D-printed vascular scaffolds with improved mechanical and antibacterial properties.
Scaffolds fabricated using PLDLA-TMC modified with PEG 400 and coated with PHMB.
Characterization of structural, thermal, mechanical, and antimicrobial properties.
Assessment of drug release, cytotoxicity, and antibacterial activity against Staphylococcus aureus.
Biocompatibility tested in endothelial cell and myoblast co-culture.
Incorporation of 2% PEG significantly increased tensile strength from 0.14 MPa to 0.79 MPa.
12% PHMB coating resulted in cell cytotoxicity with 7.70% viability.
3% PHMB coating generated a 12.5 mm inhibition zone but had rapid drug release.
6% PHMB coating maintained 72.95% cell viability and provided sustained antimicrobial release over 7 days.
Scaffolds supported organized adhesion and proliferation of cells.