Microfluidic NMR for Operando Monitoring of Drug-Induced Metabolic Fluxes in Liver Tissue Slices

Sylwia Joanna Barker; Bishnubrata Patra; Manvendra Sharma; Annamarija Raić; Ruby E. H. Karsten; Elisabeth Verpoorte; Marcel Utz

doi:10.1039/d5lc00819k

January 1, 2026Lab on a Chip

Microfluidic NMR for Operando Monitoring of Drug-Induced Metabolic Fluxes in Liver Tissue Slices

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Key Points

The aim is to develop a platform for real-time monitoring of metabolic changes in liver tissues caused by drugs.
Developed the TISuMR platform integrating microfluidics and NMR technology.
Utilized liver tissue slices to assess metabolic responses to drug exposure.
Ensured continuous and non-invasive monitoring capabilities.
Achieved high temporal resolution in detecting metabolic fluxes.
Covered a wide range of metabolites, enhancing the understanding of liver metabolism.
Demonstrated the platform's effectiveness in operando monitoring of tissue responses.

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Implication

Innovative technology monitors metabolic changes in liver slices, suggesting new drug testing methods.

Abstract

Monitoring metabolism in living tissues with high temporal resolution and broad metabolite coverage remains a major challenge. We introduce the TISuMR platform, a microfluidic Lab-on-a-Chip platform that enables continuous, non-invasive...

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Cite This Study

Barker et al. (2026) studied this question.

synapsesocial.com/papers/698585bd8f7c464f2300958c https://doi.org/10.1039/d5lc00819k

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Microfluidic NMR for Operando Monitoring of Drug-Induced Metabolic Fluxes in Liver Tissue Slices

Key Points

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Implication

Abstract

Discussion

Cite This Study

Microfluidic NMR for Operando Monitoring of Drug-Induced Metabolic Fluxes in Liver Tissue Slices

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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