Benchtop NMR for lab-on-a-chip

This is the authors' abstract. We don't add key points for this paper.

A benchtop NMR spectrometer has been designed and optimized to monitor real-time metabolism of 3D tissue engineered on microfluidic platforms using hyperpolarization by dynamic nuclear polarisation. We show the design process, which included the modification of a commercial benchtop NMR spectrometer, the design and fabrication of a microfluidic platform for a reliable injection of a hyperpolarized substrate and a constant delivery and renewal of the cell media and its integration with a RF coil for transmit/receive, and the design and fabrication of a sample carrier. We also present our preliminary NMR data using this system.