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The study aims to evaluate global trends in early-onset cancers from 1990 to 2021 and project future trends up to 2040.

February 6, 2026JCO Global OncologyOpen Access

Global Epidemiologic Trends of Early-Onset Cancers From 1990 to 2021 and Projection to 2040

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The study aims to evaluate global trends in early-onset cancers from 1990 to 2021 and project future trends up to 2040.
Analyzed data from the Global Burden of Disease 2021 study.
Calculated age-specific incidence and death rates for 31 cancer types.
Employed statistical modeling techniques for analysis and forecasting.
Approximately 23.6 million new early-onset cancer cases and 0.99 million deaths were reported in 2021.
Breast, nonmelanoma skin, and cervical cancers had the highest incidence rates.
Mortality rates have declined overall, although the incidence rate has risen.

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Assesses trends in early-onset cancers and projects future incidence and mortality, suggesting a need for strategic health interventions.

Kundu et al. (2026) studied this question.

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