Application of a human bronchoepithelial—air–liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach

Olivia C.G Lampe; Eva C.M Vitucci; Carolyn L. Cannon; Weihsueh A. Chiu; N. L. Johnson

doi:10.1080/08958378.2026.2623547

February 4, 2026Inhalation Toxicology

Application of a human bronchoepithelial—air–liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach

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Key Points

The research aims to assess the respiratory hazards of volatile organic compounds (VOCs) using an in vitro model.
Utilized a bronchoepithelial-air-liquid interface model
Investigated VOC-induced effects on airway tissues
Applied a benchmark concentration modeling approach
Demonstrated the model's effectiveness for evaluating VOC effects
Supported the model's potential for VOC safety evaluations

Implication

Benchmark modeling shows effects of VOCs on the airway, indicating a new tool for VOC safety evaluation.

Abstract

Collectively, these findings demonstrate that this model is a plausible in vitro tool to investigate VOC-induced effects on the airway and supports its utility in VOC safety evaluation.

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Cite This Study

Lampe et al. (2026) studied this question.

synapsesocial.com/papers/698585db8f7c464f230099f8 https://doi.org/10.1080/08958378.2026.2623547

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Application of a human bronchoepithelial—air–liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Application of a human bronchoepithelial—air–liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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