Key result
Light alcohol intake is linked to ~33% higher MACE risk in bias-adjusted analysis.
Why the study?
Does alcohol consumption increase the risk of cardiovascular disease and coronary artery calcium when adjusting for abstainer and sick quitter biases in adults without baseline CVD?
Population
6,814 participants aged 45-84 years without baseline cardiovascular disease from the Multi-Ethnic Study of…
Comparison
Alcohol consumption categorized as light… vs Occasional drinkers used as the reference group…
Design
Cohort
Authors
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Adjusting for abstainer and sick quitter biases reveals that even light alcohol consumption increases the risk of cardiovascular events, challenging the traditional observational findings of a cardioprotective effect from moderate drinking.
Cohort (n=6,814)
Does alcohol consumption increase the risk of cardiovascular disease and coronary artery calcium when adjusting for abstainer and sick quitter biases in adults without baseline CVD?
Hazard Ratio: 1.33 (95% CI 1.12–1.57)
Adjusting for abstainer and sick quitter biases reveals that even light alcohol consumption increases the risk of cardiovascular events, challenging the traditional observational findings of a cardioprotective effect from moderate drinking.
Srivatsa et al. (2025) conducted a cohort in Cardiovascular disease (n=6,814). Light alcohol consumption vs. Occasional drinkers (≤1 drink/week) was evaluated on Major adverse cardiovascular events (MACE) (HR 1.33, 95% CI 1.12-1.57). In bias-adjusted models using occasional drinkers as the reference, light alcohol consumption was associated with an increased risk of MACE (HR 1.33; 95% CI 1.12-1.57).
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