What question did this study set out to answer?

This study aims to evaluate the prognostic accuracy of the European LeukemiaNet genetic risk system for predicting survival in adult patients with acute myeloid leukemia.

February 6, 2026Aging and CancerOpen Access

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

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Authors

MSMobina ShresthaCollege of the Albemarle BMBishwas MandalKansas State University VMVishal MandalUniversity of Missouri

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Implication

A cohort study evaluates survival outcomes in adults with acute myeloid leukemia via genetic risk stratification, indicating tailored treatments are necessary.

Key Points

This study aims to evaluate the prognostic accuracy of the European LeukemiaNet genetic risk system for predicting survival in adult patients with acute myeloid leukemia.
Cohort of 186 adult acute myeloid leukemia patients were classified into ELN2017 risk categories: favorable, intermediate, and adverse.
Survival outcomes were analyzed, focusing on overall survival and relapse-free survival.
Subgroup analyses were performed based on clinical and molecular factors, including age and FLT3/NPM1 mutation status.
Three-year overall survival rates were 68.09% (favorable), 45.36% (intermediate), and 22.87% (adverse).
Five-year overall survival rates were 34.47% (favorable), 34.99% (intermediate), and 13.72% (adverse).
Three-year relapse-free survival rates were 49.96% (favorable), 38% (intermediate), and 12.98% (adverse).
Among FLT3-mutated patients, the 5-year overall survival was 50% for favorable and 41.10% for intermediate risk.
Allo-HSCT improved 3-year overall survival significantly in intermediate and adverse risk patients.

Cite This Study

Shrestha et al. (2026) studied this question.

synapsesocial.com/papers/698585ea8f7c464f23009a86 https://doi.org/10.1002/aac2.70018

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Implication

A cohort study evaluates survival outcomes in adults with acute myeloid leukemia via genetic risk stratification, indicating tailored treatments are necessary.

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Discussion

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Implication

Key Points

Cite This Study

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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