What question did this study set out to answer?

The aim is to compare outcomes of prenatal and postnatal surgical interventions for myelomeningocele.

February 6, 2026Neurosurgery

Prenatal Versus Postnatal Surgical Management for Myelomeningocele: A Systematic Review and Comparative Meta-Analysis

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Authors

GSGabriel Semine ALAnna Laura Lima LarciprettiUniversidade Federal de Ouro Preto LRLeonardo Antônio Silveira RitossaUniversidade Federal do Triângulo Mineiro

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Implication

This systematic review compares prenatal and postnatal surgical management outcomes for myelomeningocele, suggesting implications for treatment choices.

Key Points

The aim is to compare outcomes of prenatal and postnatal surgical interventions for myelomeningocele.
Conducted a systematic review and meta-analysis following PRISMA guidelines.
Searched databases including Embase, PubMed, and Web of Science for relevant articles.
Included studies with comparative cohorts of more than 4 patients with myelomeningocele.
Calculated risk ratios (RR) for various outcomes using a random-effect model.
No significant differences in mortality or tethered cord syndrome between prenatal and postnatal groups.
Prenatal repair was associated with lower rates of hydrocephalus, shunt placement, and motor dysfunctions.
Hydrocephalus developed in 557 patients, showing a significant favor toward prenatal repair (RR 0.48).
Shunt placement occurred in 360 patients, significantly favoring prenatal repair (RR 0.50).
Motor dysfunctions were significantly less common in the prenatal group (RR 0.59).

Cite This Study

Semine et al. (2026) studied this question.

synapsesocial.com/papers/698585fe8f7c464f23009ca2 https://doi.org/10.1227/neu.0000000000003937

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Implication

This systematic review compares prenatal and postnatal surgical management outcomes for myelomeningocele, suggesting implications for treatment choices.

Prenatal Versus Postnatal Surgical Management for Myelomeningocele: A Systematic Review and Comparative Meta-Analysis

Discussion

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Implication

Key Points

Cite This Study

Prenatal Versus Postnatal Surgical Management for Myelomeningocele: A Systematic Review and Comparative Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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