Key result
Lead-less pacemakers are linked to ~66% higher mortality vs traditional pacemakers, despite fewer device complications.
Why the study?
Traditional transvenous pacemakers carry lead-related complications, and lead-less pacemakers emerged to potentially reduce these issues, warranting a comparative evaluation of efficacy and safety.
Do lead-less pacemakers reduce mortality and complications compared to traditional transvenous pacemakers in patients requiring cardiac pacing?
Meta-Analysis (n=475,005)
Do lead-less pacemakers reduce mortality and complications compared to traditional transvenous pacemakers in patients requiring cardiac pacing?
Effect estimate: RR 1.66 (95% CI 1.13-2.46)
p-value: p=0.01
While lead-less pacemakers reduce device-related complications, they are associated with a significantly higher risk of all-cause mortality and pericardial effusion compared to traditional transvenous pacemakers.
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Warrants caution against the routine first-line use of lead-less pacemakers.
Islam et al. (2025) conducted a meta-analysis in Patients requiring cardiac pacing (n=475,005). Lead-less pacemakers vs. Traditional transvenous pacemakers was evaluated on All-cause mortality (RR 1.66, 95% CI 1.13-2.46, p=0.01). Lead-less pacemakers were associated with higher all-cause mortality (RR 1.66; 95% CI 1.13-2.46; p=0.01) and pericardial effusion, but fewer device-related complications than traditional pacemakers.
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