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February 6, 2026Open Access

Levothyroxine and Liothyronine in Hypothyroidism: A Comparative Review of Safety and Efficacy

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Authors

MJM. Vijayalakshmi*1, K. Gajalakshmi1, V. Krishnan1, S. Pragadheesh1, Mr. M. Praveen Kumar2, Dr. C. Jothimanivannan3

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Overview

Comparative review assesses safety and efficacy of levothyroxine and liothyronine in hypothyroidism, suggesting further investigation is needed.

Key Points

  • This review aims to evaluate the safety and efficacy of levothyroxine and liothyronine in managing hypothyroidism.
  • Summarized epidemiological data on hypothyroidism prevalence in the US population
  • Reviewed physiologic mechanisms involving the hypothalamic-pituitary-thyroid axis
  • Analyzed clinical trials on combination therapy using levothyroxine and liothyronine
  • Evaluated impacts on symptoms and quality of life in patients under various treatment regimens
  • Levothyroxine monotherapy effectively achieves biochemical euthyroidism in most patients.
  • Combination therapy (levothyroxine and liothyronine) shows mixed results on improving persistent symptoms.
  • Current evidence classifies combination therapy as experimental and not FDA-approved.

Cite This Study

M. Vijayalakshmi*1, K. Gajalakshmi1, V. Krishnan1, S. Pragadheesh1, Mr. M. Praveen Kumar2, Dr. C. Jothimanivannan3 (2026) studied this question.

synapsesocial.com/papers/698586388f7c464f2300a393https://doi.org/10.5281/zenodo.18480946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of T3 in Management of Hypothyroidism2025
  2. 2Personalized Approaches to Hypothyroidism: The Role of Triiodothyronine (T3) in Thyroid Hormone Replacement2025
  3. 3Effect of levothyroxine plus liothyronine combination therapy on hypothyroid patients quality of life2020
  4. 4Use of thyroid hormones in hypothyroid and euthyroid patients: A survey of members of the Endocrine Society of Australia2024 · 10 citations
  5. 5Studying the Role of L-Thyroxine in Long-Term Management of Hypothyroidism: A Comparative Analysis with Healthy Control2024