Key result
Moderate AS linked to ~14% lower survival compared to the general population.
Why the study?
Moderate aortic stenosis is often considered relatively benign, but data describing mortality throughout the disease course and its prognostic factors are needed.
Does moderate aortic stenosis reduce survival compared to the general population in asymptomatic adults with preserved ejection fraction?
Cohort (n=605)
Does moderate aortic stenosis reduce survival compared to the general population in asymptomatic adults with preserved ejection fraction?
Effect estimate: Relative survival 86%
Moderate aortic stenosis is not a benign condition, as it is associated with significantly lower survival compared to the age- and sex-matched general population.
Authors
No takes yet. Share an insight, caveat, or question.
Moderate aortic stenosis was associated with reduced survival; challenges benign-prognosis consensus but leaves open causal role and intervention thresholds.
Iroulart et al. (2025) conducted a cohort in Moderate aortic stenosis (n=605). Moderate aortic stenosis vs. Age- and sex-matched general population was evaluated on All-cause mortality (Relative survival 86%). Moderate aortic stenosis in asymptomatic patients was associated with an unfavorable disease course, demonstrating a relative survival rate of 86% compared to the matched general population.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: