Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle

Vignesh Sathyaseelan; John Morgan; Brett M. Savoie

doi:10.1039/d5sc05872d

January 1, 2026Chemical ScienceOpen Access

Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle

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Key Points

This research investigates the kinetic aspects of the reverse tricarboxylic acid cycle as a prebiotic carbon fixation strategy.
Utilized reaction exploration algorithms to analyze kinetic pathways.
Examined prebiotic analogs related to the rTCA cycle.
Assessed CO2 fixation mechanisms in primitive systems.
Identified conditions under which kinetics dominate over thermodynamics.
Showed potential for rTCA cycles in prebiotic environments.
Revealed insights into the evolution of metabolic pathways.

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Implication

This research explores kinetic viability of prebiotic carbon fixation in evolutionary pathways, suggesting new perspectives on early metabolism.

Abstract

The reverse/reductive tricarboxylic acid (rTCA) cycle is a highly conserved CO 2 fixation pathway and candidate for prebiotic carbon fixation. The kinetic viability of prebiotic hypotheses are studied here using reaction exploration algorithms.

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Sathyaseelan et al. (2026) studied this question.

synapsesocial.com/papers/698586ad8f7c464f2300a743 https://doi.org/10.1039/d5sc05872d

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Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle

Key Points

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Implication

Abstract

Discussion

Cite This Study

Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle

Key Points

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Implication

Abstract

Discussion

Cite This Study

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