Population
Isolated perfused rat hearts
Comparison
K+-induced arrest of the heart and incorporation… vs Steady-state conditions
Design
Preclinical
Authors
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Supports myocardial anaplerosis via CO2 fixation under low ATP demand; leaves open relevance to human cardiac metabolism.
This preclinical study demonstrates that CO2 fixation contributes to anaplerosis in the myocardium, with its rate dependent on the metabolic state and ATP consumption.
Nuutinen et al. (1981) studied this question.
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