Key result
Computer simulation of the rat heart TCA cycle predicts succinate accumulation during higher work output.
Population
Computer simulation model of pyruvate-perfused rat heart
Design
Preclinical
Authors
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Highlights Mg2+ regulation of TCA cycle in stressed rat hearts; hypothesis-generating for human cardiac metabolism.
This computational model highlights the critical regulatory role of unchelated Mg2+ in the tricarboxylic acid cycle of the rat heart during increased workload.
Köhn et al. (1979) studied Metabolism in perfused rat heart. Large increase in work load was evaluated on Sequence of biochemical events regulating the metabolism of exogenous pyruvate. A computer simulation of the tricarboxylic acid cycle in the perfused rat heart predicted an accumulation of succinate during the transition to higher work output.
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