Key result
A computational model of atrial myocyte metabolism successfully reproduced steady-state dynamics and demonstrated that increased simulated cardiac workload leads to increased intracellular glucose and decreased ATP concentrations.
Population
Computational model of an atrial cell
Comparison
Dynamic modulated cardiac workload vs control conditions
Design
Computational modeling study
Authors
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Enables simulation of atrial metabolic stress responses; leaves open validation in human disease models before research utility.
This computational model of atrial myocyte metabolism successfully simulates the energy demand-supply balance under varying workloads, providing a tool to explore metabolic dysfunction in cardiac diseases.
Ijebu et al. (2018) studied Cardiac metabolism in atrial myocytes. Simulated modulated cardiac workload (pacing frequency switch) vs. Baseline frequency (0.25Hz) was evaluated on Steady state dynamics of cytosolic and mitochondrial metabolic substrates and ATP concentration. A computational model of atrial myocyte metabolism successfully reproduced steady-state dynamics and demonstrated that increased simulated cardiac workload leads to increased intracellular glucose and decreased ATP concentrations.
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