Key result
A novel mechanistic model with a cytosolic subdomain for glycolysis effectively predicted the rapid activation of glycogen breakdown and lactate production at the onset of ischemia.
A novel mechanistic model incorporating a cytosolic subdomain for glycolysis accurately predicts the rapid activation of glycogen breakdown and lactate production during myocardial ischemia.
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May guide subcellular metabolic modeling in ischemia research; leaves open human translation.
Zhou et al. (2005) studied Myocardial ischemia. Multidomain mathematical model with a cytosolic subdomain for glycolysis vs. Previous model without compartmentation was evaluated on Simulation of metabolic responses to reduced myocardial blood flow (glycogen breakdown and lactate production). A novel mechanistic model with a cytosolic subdomain for glycolysis effectively predicted the rapid activation of glycogen breakdown and lactate production at the onset of ischemia.
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