Population
Perfused rat heart model
Comparison
Acetate perfusion vs Control perfusions (glucose oxidation)
Design
Preclinical
Follow-up
12 minutes
Authors
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Acetate may shift myocardial substrate preference in rats; leaves open whether similar dynamics affect human cardiac metabolism or therapy.
In the perfused rat heart, acetate utilization suppresses glucose oxidation and increases tricarboxylate-cycle turnover, suggesting the cycle operates in two spans controlled by citrate synthase and 2-oxoglutarate dehydrogenase.
Randle et al. (1970) studied this question.
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