March 1, 1995AJP Endocrinology and Metabolism
Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: validation with syntactic model
Key result
New mathematical formula estimates absolute cardiac citric acid cycle flux without solving differential equations.
Population
Syntactic model of the citric acid cycle (CAC) in myocytes
Comparison
New mathematical method/formula for estimating… vs Empirical measure (KT) proposed by Weiss et al.
Authors
Discussion
Loading...
Member takes
Implication
Simplifies cardiac citric acid cycle flux estimation in research; extends methodological tools but leaves clinical translation open.
Structured PICO
P
Population
Syntactic model of the citric acid cycle (CAC) in myocytes
I
Intervention
New mathematical method/formula for estimating the absolute rate of flux through the CAC (vTCA), aspartate aminotransferase (vTA), and NADP(+)-dependent malic enzyme
C
Comparator
Empirical measure (KT) proposed by Weiss et al.
O
Outcome
Absolute rate of flux through the CAC (vTCA)
A new mathematical formula allows for the estimation of the absolute rate of flux through the citric acid cycle in the heart without requiring numerical solutions of differential equations.
Cite This Study
Cohen et al. (1995) studied this question. New mathematical method for estimation of vTCA vs. Numerical solution of differential equations and empirical measure (KT) was evaluated on Estimation of the absolute rate of the flux through the citric acid cycle (vTCA). A new mathematical formula was developed to estimate the absolute rate of flux through the citric acid cycle in the heart without requiring the numerical solution of differential equations.