Demonstrates how LRP8 enhances colorectal cancer progression by inhibiting ferroptosis, suggesting new therapeutic targets.
LRP8 facilitates CRC progression by antagonizing ferroptosis via modulation of the SLC3A2/GPX4 signalling axis. These findings highlight LRP8 as a previously unrecognized regulator of ferroptotic vulnerability and a potential therapeutic target in CRC.
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Zhu et al. (2026) studied this question.
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