What question did this study set out to answer?

The study aims to examine how maternal nutrition affects gene and mRNA expression in the skeletal muscle of beef cattle offspring.

February 8, 2026Frontiers in GeneticsOpen Access

Maternal nutrition alters mRNA isoform expression, usage, and splicing dynamics in skeletal muscle of beef cattle offspring

View Full Paper

Ask AI

Bookmark

The study aims to examine how maternal nutrition affects gene and mRNA expression in the skeletal muscle of beef cattle offspring.
Assigned 126 pregnant Nellore cows to three dietary treatments: NP, PP, and FP.
Collected muscle samples from offspring at 676 ± 28 days of age for RNA sequencing.
Analyzed differential gene expression and transcript usage using edgeR and IsoformSwitchAnalyzeR packages.
Conducted over-representation analysis with g:Profiler.
Identified 27,412 genes and 111,185 transcripts, with modest gene-level differences (16 genes) but stronger transcript-level effects.
FP × NP showed the greatest transcript usage changes with 14 DTEs and 87 DTUs.
Isoform switching in key genes like SLC7A8 and SORBS3 affected coding potential and muscle function.
Significant metabolic pathways related to amino acid metabolism and immune regulation were highlighted.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Experimental analysis reveals prenatal nutrition impacts muscle gene expression and splicing in cattle offspring, indicating long-term metabolic adaptations.

Cite This Study

Polizel et al. (2026) studied this question.

synapsesocial.com/papers/698827570fc35cd7a8845f3c https://doi.org/10.3389/fgene.2026.1734234

View Full Paper

Ask AI

Bookmark

Implication

Experimental analysis reveals prenatal nutrition impacts muscle gene expression and splicing in cattle offspring, indicating long-term metabolic adaptations.

Maternal nutrition alters mRNA isoform expression, usage, and splicing dynamics in skeletal muscle of beef cattle offspring

Key Points

Discussion

Implication

Cite This Study

Maternal nutrition alters mRNA isoform expression, usage, and splicing dynamics in skeletal muscle of beef cattle offspring

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider