Explores gene expression in multidrug resistant Klebsiella pneumoniae, suggesting new therapeutic targets for resistance reversal.
Our integrated findings indicate that higher marA/soxS expression is associated with increased gene expression of the AcrAB-TolC efflux pump and fluoroquinolone resistance in clinical MDR isolates, while PAβN-mediated efflux inhibition is associated with partial susceptibility restoration. Together, these results highlight global regulators and efflux pumps as actionable therapeutic targets for resistance reversal.
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Obaid et al. (2026) studied this question.
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