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February 8, 20260 citations

Combination therapy with bone marrow-derived mesenchymal stem cell transplantation and propolis improves streptozotocin-induced kidney injury in diabetic rats.

FSFatemeh SalamiSHSara HosseinianEMElahe Mahdipour

Key Points

  • To evaluate the effects of combined therapy with mesenchymal stem cells and propolis on kidney injury in diabetic rats.
  • Induced diabetic nephropathy in rats using streptozotocin (STZ)
  • Administered bone marrow-derived mesenchymal stem cells (MSCs) and propolis
  • Assessed renal function, kidney index, and histopathological changes
  • Improvement in renal function observed in treated groups compared to STZ diabetic rats
  • Kidney index showed positive changes in all treated animals
  • Histopathological examination indicated reduced kidney damage comparable to metformin

Abstract

Our findings demonstrated, MSCs, propolis, and their combination demonstrate positive effects on renal function, kidney index, and histopathology in all treated animals compared with the STZ diabetic rats. These beneficial effects are comparable to those of metformin.

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Cite This Study

Salami et al. (2026) studied this question.

synapsesocial.com/papers/698827670fc35cd7a884620bhttps://doi.org/10.22038/ajp.2025.26229
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