Key result
ICE-guided AlphaVac thrombectomy shows feasibility for treating thrombus-in-transit and PE in high-risk patients.
Why the study?
Impending paradoxical embolism (IPE) in acute pulmonary embolism (PE) is rare and associated with high mortality, with limited data on ICE-guided mechanical thrombectomy for simultaneous treatment of right ventricular thrombus-in-transit, IPE, and high-risk PE.
Case Report (n=1)
ICE-guided percutaneous thrombectomy is a feasible treatment option for high-risk patients with simultaneous right ventricular thrombus-in-transit, impending paradoxical embolism, and pulmonary embolism.
OBJECTIVE: Impending paradoxical embolism (IPE), defined as thrombus entrapped across a patent foramen ovale, is rare in acute pulmonary embolism (PE) and is associated with high mortality. We present to our knowledge the first successful intracardiac echocardiography (ICE)-guided mechanical thrombectomy for simultaneous treatment of right ventricular thrombus-in-transit (TIT), IPE, and high-risk PE. KEY STEPS: system into the right atrium. Under ICE guidance, aspiration evacuated the TIT and IPE, followed by catheter-based pulmonary thrombectomy. POTENTIAL PITFALLS: Percutaneous thrombectomy is feasible for patients unsuitable for surgery or thrombolysis but carries a risk of paradoxical embolization. Embolic protection is therefore essential. TAKE-HOME MESSAGE: ICE-guided AlphaVac thrombectomy of TIT, IPE, and PE is feasible in high-risk patients.
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Kam et al. (2026) conducted a case report in Impending paradoxical embolism, right ventricular thrombus-in-transit, and high-risk pulmonary embolism (n=1). ICE-guided mechanical thrombectomy (AlphaVac) was evaluated on Procedural success and feasibility. ICE-guided AlphaVac mechanical thrombectomy was feasible and successful for the simultaneous treatment of right ventricular thrombus-in-transit, impending paradoxical embolism, and high-risk pulmonary embolism.
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