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February 8, 2026Clinical Case Reports0 citationsOpen Access

Methanol Induced Optic Neuropathy: An Unusual Case With the Absence of Classic Symptoms

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HTHumza TariqAGAli GoharMAMuhammad Husnain Ahmad

Key Points

  • This case aims to highlight the unusual presentation of methanol toxicity leading to optic neuropathy.
  • Reported case of an 18-year-old boy with sudden bilateral visual loss.
  • Assessment included pupil examination and fundus evaluation.
  • Conservative treatment with high-dose steroids and ethanol was implemented.
  • Diagnosis confirmed through toxicology report and imaging studies.
  • Patient's visual acuity improved from no perception of light to hand movement over two weeks.
  • Normal arterial blood gases indicated stability despite methanol toxicity.
  • Visual loss was linked to optic neuropathy, highlighting severity of methanol exposure.

Abstract

ABSTRACT Methanol toxicity is an emergency that doctors come across all around the globe, requiring immediate treatment or it can cause life‐threatening conditions affecting the central nervous system, causing toxic optic neuropathy and metabolic acidosis. We present a case of an 18‐year‐old boy, who presented in the medicine emergency with sudden bilateral visual loss and vomiting. He did not have any significant past medical history and all of his examinations were normal except bilaterally dilated pupils and the fundus examination showing bilateral optic disc pallor and cup to disc (C/D) ratio 0.5 and his visual acuity was no perception of light (NPL). He was admitted and treated conservatively with high‐dose steroids and ethanol. Later on, a diagnosis of methanol toxicity was made based on toxicology report and imaging studies. His ABGs remained normal throughout and his vision improved to hand movement (HM) over the course of 2 weeks. Methanol toxicity can vary in presentation and could lead to toxic optic neuropathy causing sudden total visual loss. It usually occurs as an outbreak so cases like these should be reported to have a general awareness about it; aiding in early detection, timely management and better public health strategies.

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Cite This Study

Tariq et al. (2026) studied this question.

synapsesocial.com/papers/6988277b0fc35cd7a884639chttps://doi.org/10.1002/ccr3.71989
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