Demonstrates nematicidal activity against Meloidogyne incognita in oleanolic acid derivatives, suggesting potential for nematode control.
In this study, four 3 O-acylated derivatives of oleanolic acid (1a-1d) have been prepared. Compounds 3-β-[2-Triflouromethylbenzoyloxy]-olean-12-en-28-oic acid (1c) and 3-β-[4-Triflouromethylbenzoyloxy]-olean-12-en-28-oic acid (1d) are new and 3-β-[Benzoyloxy]-olean-12-en-28-oic acid (1a) and 3-β-Dichloroacetoxy-olean-12-en-28-oic acid (1b) have synthesized earlier. Their nematicidal activity against root knot nematode Meloidogyne incognita was determined and compared with the standard nematicide furadan. These derivatives were characterized through UV, IR and 1H-NMR. Oleanolic acid (1) was found to be most active with 75% toxicity and among these derivatives, 2-triflouromethyl benzoyl derivative (1c) showed highest toxicity 74% at 1% concentration. This is the first report of the nematicidal activity of these derivatives of oleanolic acid. published by the Journal of Biodiversity and Environmental Sciences | JBES
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Ayub Anjum (2021) studied this question.
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