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This research investigates how interleukin signaling affects T-cell function alongside Src/BCR-ABL1 blockade in Philadelphia chromosome-positive acute lymphoblastic leukemia.

February 8, 2026HaematologicaOpen Access

Interleukin signaling mitigates the inhibitory effects of combined Src/BCR-ABL1 blockade on T-cell activity in Philadelphia chromosome-positive acute lymphoblastic leukemia

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Authors

FNFarnaz NaeemikiaPennsylvania State University JRJoshua ReynoldsPennsylvania State University CDCheng DongPennsylvania State University

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Implication

Investigating interleukin effects on T-cell activity with Src/BCR-ABL1 inhibition in Ph+ ALL, suggesting enhanced therapies.

Key Points

This research investigates how interleukin signaling affects T-cell function alongside Src/BCR-ABL1 blockade in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Combining tyrosine kinase inhibitors with blinatumomab in vitro
Assessing T-cell proliferation and activation via LCK Y394 phosphorylation
Exploring effects of interleukin supplementation on T-cell responses
Dasatinib and ponatinib reduce T-cell activation by blocking LCK phosphorylation
IL-7 supplementation improves T-cell proliferation and reduces exhaustion
Enhanced blinatumomab efficacy is observed in the context of Src/BCR-ABL1 TKIs with interleukin treatment

Cite This Study

Naeemikia et al. (2026) studied this question.

synapsesocial.com/papers/6988278b0fc35cd7a88466f9 https://doi.org/10.3324/haematol.2025.288829

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Interleukin signaling mitigates the inhibitory effects of combined Src/BCR-ABL1 blockade on T-cell activity in Philadelphia chromosome-positive acute lymphoblastic leukemia

Discussion

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Implication

Key Points

Cite This Study

Interleukin signaling mitigates the inhibitory effects of combined Src/BCR-ABL1 blockade on T-cell activity in Philadelphia chromosome-positive acute lymphoblastic leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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