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February 8, 2026Diagnostics0 citationsOpen Access

Molecular Landscape of Resected Thymomas Through Mutational Profiling

Molecular Landscape of Resected Thymomas: Insights from Mutational Profiling

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Authors

LFLuca FrascaASAntonio SarubbiLNLorenzo Nibid

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Overview

Explores mutational profiling and PD-L1 expression in resected thymomas, suggesting implications for targeted therapy.

Key Points

  • Investigate targetable mutations and PD-L1 expression in resected thymomas, and their association with disease recurrence.
  • Conducted mutational profiling using a DNA-based NGS Cancer Panel of 16 genes.
  • Evaluated PD-L1 expression via Tumor Proportion Score (TPS).
  • Analyzed associations with histological subtype and disease-free survival using logistic regression and Cox models.
  • Identified PIK3CA mutations in 5.4% of tested thymomas.
  • Found high PD-L1 expression (≥50%) in 40.5% of patients, linked to aggressive histological subtypes (B2 and B3).
  • High PD-L1 expression predicted aggressive histology with an odds ratio of 15.5 (p = 0.001).
  • Observed a 13.5% recurrence rate but no significant difference in disease-free survival between expression levels.

Cite This Study

Frasca et al. (2026) studied this question.

synapsesocial.com/papers/698827a20fc35cd7a8846756https://doi.org/10.3390/diagnostics16030484
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