What question did this study set out to answer?

To evaluate PD-L1 expression in papillary thyroid carcinoma and its variants and assess its prognostic value for clinical outcomes.

April 12, 2016OncotargetOpen Access

Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants

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Authors

SCSubrata ChowdhuryMount Sinai Hospital JVJoe VeyhlMount Sinai Hospital FJFatima JessaUniversity Health Network

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Implication

Retrospective study demonstrates that PD-L1 overexpression reduces disease-free survival in papillary thyroid cancer, highlighting its value as a prognostic biomarker.

Key Points

To evaluate PD-L1 expression in papillary thyroid carcinoma and its variants and assess its prognostic value for clinical outcomes.
Retrospectively analyzed PD-L1 protein expression via immunohistochemistry in 251 archived formalin-fixed paraffin-embedded surgical tissues (185 papillary thyroid carcinomas and 66 benign thyroid nodules) using a rabbit monoclonal antibody (E1L3N).
Assessed clinicopathological features and clinical outcomes over 190 months of follow-up, correlating subcellular PD-L1 localization with disease-free survival using Kaplan-Meier and Cox multivariate regression analyses.
Tumors with increased PD-L1 membrane or cytoplasmic positivity showed significantly reduced median disease-free survival of 36 months (p < 0.001) and 49 months (p < 0.01), respectively, compared to 186 months for PD-L1-negative tumors.
Cytoplasmic PD-L1 positivity across stages I through IV correlated with increased recurrence risk and poor prognosis, whereas membrane positivity was significantly associated with metastasis or death exclusively in stage IV patients.

Cite This Study

Chowdhury et al. (2016) studied this question.

synapsesocial.com/papers/69d978c9387cf7069868426c https://doi.org/10.18632/oncotarget.8698

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Implication

Retrospective study demonstrates that PD-L1 overexpression reduces disease-free survival in papillary thyroid cancer, highlighting its value as a prognostic biomarker.

Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants

Discussion

Member takes

Implication

Key Points

Cite This Study

Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants

Discussion

Member takes

Implication

Key Points

Cite This Study

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