AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.

Qinghua Li; Qingdong Bao; Chaoqun Wei; Yanshuo Xie; Sihan Zhao; Hui Yan; Fan Wu; Wenlong Li; Xia Liu; Hua Gao

doi:10.1167/iovs.67.2.22

February 2, 2026

AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.

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Key Points

This research aims to investigate how AIF-1 influences corneal neovascularization (CNV) through macrophage activation.
Analyzed the role of AIF-1 in corneal inflammation and neovascularization.
Examined activation of inflammatory macrophages using signaling pathway assays.
Utilized MAPK and PI3K/AKT/mTOR pathway analyses.
AIF-1 significantly increased inflammatory macrophage activation.
The activation led to enhanced corneal neovascularization and inflammation.
Key signaling pathways (MAPK and PI3K/AKT/mTOR) were identified as crucial mediators.

Implication

Molecular analysis demonstrates AIF-1's role in enhancing inflammatory macrophage activation, indicating potential CNV treatment pathways.

Abstract

AIF-1 played a pivotal role in CNV progression. AIF-1 promoted inflammatory macrophage activation, exacerbating corneal inflammation and neovascularization via the MAPK and PI3K/AKT/mTOR signaling pathways, which offers novel insights for CNV treatment.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/698827a20fc35cd7a8846876 https://doi.org/10.1167/iovs.67.2.22

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AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.

Key Points

Implication

Abstract

Discussion

Cite This Study

AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.

Key Points

Implication

Abstract

Discussion

Cite This Study

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