CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD

Abdoulaye Dabo; Patrick Geraghty; Oleg V. Evgrafov; Michael Campos; Eran Hadas; Boe-Hyun Kim; Mary Jane Potash; David J. Volsky; Robert F. Foronjy

doi:10.1186/s12931-026-03495-8

February 5, 2026Respiratory ResearchOpen Access

CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD

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Key Points

To investigate how CXCL11 levels influence lung Treg responses in the context of HIV-related COPD.
Examined the effects of cigarette smoke on CXCL11 levels.
Assessed lung Treg responses in HIV-infected individuals.
Analyzed the role of c-Src in modulating CXCL11 levels.
Cigarette smoke reduced CXCL11 levels.
Lower CXCL11 levels led to decreased lung Treg responses.
Impaired Treg responses were linked to increased lung tissue damage.

Implication

Findings reveal how cigarette smoke impacts CXCL11, affecting lung Treg responses in HIV-infected individuals, suggesting new intervention strategies.

Abstract

These findings indicate that cigarette smoke activates c-Src to suppress CXCL11 levels thereby diminishing lung Treg responses that counter airways disease and lung tissue destruction in HIV-infected individuals.

Discussion

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Cite This Study

Dabo et al. (2026) studied this question.

synapsesocial.com/papers/698828010fc35cd7a8847167 https://doi.org/10.1186/s12931-026-03495-8

View Full Paper

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CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD

Key Points

Implication

Abstract

Discussion

Cite This Study

CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD

Key Points

Implication

Abstract

Discussion

Cite This Study

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