What question did this study set out to answer?

To investigate how CXCL11 levels influence lung Treg responses in the context of HIV-related COPD.

February 8, 2026Open Access

CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD

Key Points

To investigate how CXCL11 levels influence lung Treg responses in the context of HIV-related COPD.
Examined the effects of cigarette smoke on CXCL11 levels.
Assessed lung Treg responses in HIV-infected individuals.
Analyzed the role of c-Src in modulating CXCL11 levels.
Cigarette smoke reduced CXCL11 levels.
Lower CXCL11 levels led to decreased lung Treg responses.
Impaired Treg responses were linked to increased lung tissue damage.

Abstract

These findings indicate that cigarette smoke activates c-Src to suppress CXCL11 levels thereby diminishing lung Treg responses that counter airways disease and lung tissue destruction in HIV-infected individuals.

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