Myosin IXb is involved in multiple pathological conditions

Figures

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  Figure 1. Schematic diagram of Myo9b/RhoA (left panel) within the epithelial barrier (right panel). The paracellular transport of molecules through epithelial barrier is regulated by the tight junctions complex, adherens junctions and desmosomes. The tight junction complex is connected with the actomyosin cytoskeleton (Prager et al., 2014; Kong et al., 2015).

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  Figure 2. The role of Myo9b in various tumor metastasis processes. The signaling pathways of Myo9b in promoting cancer cell invasion and metastasis in breast cancer, prostate cancer (A), lung cancer (B) and malignant pleural effusion (C) (Kong et al., 2015; Yi et al., 2020; Boulton et al., 2025). (A) Miro2 supports the metastatic potential of breast and prostate epithelial cancer cells by froming a complex with Myo9b, and then suppresses RhoA activity. Myo9b-dependent cell invasion requires its GAP activity and Miro2 expression. (B) Working model depicting the SLIT/ROBO signal transduction pathway involving Myo9b and RhoA. SLIT interacts with the transmembrane receptor ROBO to inhibit lung cancer cell migration in a ROBO-dependent manner. The ICD of ROBO (RPBP-ICD) binds to the RhoGAP domain of Myo9b and suppresses its GAP activity in converting GTP-RhoA to GDP-RhoA, leading to increased levels of GTP-RhoA and a subsequent suppression of cell invasion and migration. (C) Working model depicting that Myo9b deficiency of MC38 cells disabled migration, thereby reducing MPE development. The Myo9b/TSAd pathway regulated MPE accumulation by adjusting the TH1/TH17 cell response.