Key result
Class IX myosins Myo9a and Myo9b negatively regulate RhoA signaling, with Myo9a regulating epithelial cell morphology and Myo9b controlling macrophage shape and motility.
Class IX myosins play distinct roles in cellular morphology and motility by negatively regulating RhoA signaling.
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Mammals contain two class IX myosins, Myo9a and Myo9b. They are actin-based motorized signalling molecules that negatively regulate RhoA signalling. Myo9a has been implicated in the regulation of epithelial cell morphology and differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility.
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No immediate clinical implications; extends RhoA-myosin insights in cell motility but leaves open cardiovascular translation.
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Bähler et al. (2011) studied this question. Class IX myosins Myo9a and Myo9b negatively regulate RhoA signaling, with Myo9a regulating epithelial cell morphology and Myo9b controlling macrophage shape and motility.
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