Key result
Recent systemic sclerosis is linked to impaired global work efficiency compared to matched controls.
Why the study?
Are there early changes in myocardial mechanics in recently-diagnosed asymptomatic patients with systemic sclerosis compared to matched controls?
Population
20 asymptomatic patients recently diagnosed with systemic sclerosis with low echocardiographic probability…
Design
Case-control
Authors
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Impaired left and right ventriculo-arterial coupling is present early after systemic sclerosis diagnosis and can be detected using myocardial work parameters and TAPSE/sPAP ratio.
Case-Control (n=40)
Are there early changes in myocardial mechanics in recently-diagnosed asymptomatic patients with systemic sclerosis compared to matched controls?
Absolute Event Rate: 93.2% vs 95.3%
p-value: p=0.026
Impaired left and right ventriculo-arterial coupling is present early after systemic sclerosis diagnosis and can be detected using myocardial work parameters and TAPSE/sPAP ratio.
Andrei et al. (2025) conducted a case-control in Systemic sclerosis (n=40). Systemic sclerosis vs. Matched controls was evaluated on Global work efficiency (GWE) (p=0.026). Recently diagnosed systemic sclerosis is associated with impaired global work efficiency (93.2% vs 95.3%; p=0.026) and higher global wasted work compared to matched controls.
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