What question did this study set out to answer?

To examine the heterogeneity of EGFR mutations across different contexts and samples in non-small cell lung cancer (NSCLC).

February 8, 2026Molecular Diagnosis & Therapy4 citationsOpen Access

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis

DSDiana Ivonne Rodríguez Sánchez SÖSelin Asli Öztürk OMOlga Maxouri

Key Points

To examine the heterogeneity of EGFR mutations across different contexts and samples in non-small cell lung cancer (NSCLC).
Conducted a systematic review of existing studies on EGFR mutations in NSCLC.
Performed a meta-analysis to derive pooled estimates from various sampling strategies and contexts.
Analyzed discrepancies based on factors such as biofluid and metastatic site.
EGFR mutation discordance observed frequently across studies.
Variability in mutation types noted depending on the sampling approach and treatment context.
Pooled estimates highlight the need for context-aware strategies in EGFR-targeted therapies.

Abstract

EGFR mutation discordance is common and clinically relevant, particularly in NSCLC, but varies substantially by sampling strategy, biofluid, treatment context, and metastatic site. Given the high between-study heterogeneity and the predominance of NSCLC and Asian cohorts, pooled estimates should be interpreted as descriptive summaries rather than universally generalisable benchmarks. These findings support integrated and context-aware sampling strategies for EGFR-targeted therapy and resistance monitoring.

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/698828410fc35cd7a884793a https://doi.org/10.1007/s40291-026-00829-6

Ask AI

Helpful

Bookmark

View Full Paper

February 8, 2026Molecular Diagnosis & Therapy4 citationsOpen Access

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis

DSDiana Ivonne Rodríguez Sánchez SÖSelin Asli Öztürk OMOlga Maxouri

Key Points

To examine the heterogeneity of EGFR mutations across different contexts and samples in non-small cell lung cancer (NSCLC).
Conducted a systematic review of existing studies on EGFR mutations in NSCLC.
Performed a meta-analysis to derive pooled estimates from various sampling strategies and contexts.
Analyzed discrepancies based on factors such as biofluid and metastatic site.
EGFR mutation discordance observed frequently across studies.
Variability in mutation types noted depending on the sampling approach and treatment context.
Pooled estimates highlight the need for context-aware strategies in EGFR-targeted therapies.

Abstract

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/698828410fc35cd7a884793a https://doi.org/10.1007/s40291-026-00829-6

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Ask AI

Helpful

Bookmark

View Full Paper